Association between TNIP1, MPHOSPH6 and ZNF208 genetic polymorphisms and the coronary artery disease risk in Chinese Han population

Abstract

// Yanbin Song 1, 2, 3 , Mengdan Yan 1, 2 , Jing Li 1, 2 , Jingjie Li 1, 2 , Tianbo Jin 1, 2 and Chao Chen 1, 2 1 Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an, Shaanxi 710069, China 2 School of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China 3 Department of Cardiovascular, Yanan University Affiliated Hospital, Yanan, Shaanxi 716000, China Correspondence to: Tianbo Jin, email: tianbojin1973@163.com Chao Chen, email: chaochenxd@gmail.com Keywords: coronary artery disease (CAD), polymorphisms, ZNF208, TNIP1, MPHOSPH6 Received: May 18, 2017      Accepted: June 24, 2017      Published: August 24, 2017 ABSTRACT Introduction: Coronary artery disease (CAD) is a common disease and among the leading cause of death in the general population. Inherited factors are involved in the pathogenesis of CAD. Aims: Our study examined whether SNPs in TNIP1, MPHOSPH6, ZNF208 to be associated with CAD risk in a Chinese Han population. We recruited 596 CAD patients, 603 controls and genotyping fifteen SNPs using Sequenom MassARRAY. For association analysis between TNIP1, MPHOSPH6 and ZNF208 and CAD was determined by Odds ratios (ORs) with 95% confidence intervals (CIs) using Logistic Regression. Results: The results indicated in allel model, the rs960709 in TNIP1 was associated with CAD risk (OR = 0.78, 95%CI = 0.65-0.94, P=0.010). The genetic model results showed that the rs960709 (A/G) polymorphism was associated with the risk of developing CAD in codominant, Dominant and Log-additive. The rs1056654 A/A allele and CAD patients compared to the healthy controls in recessive model (OR = 0.55, 95%CI = 0.34-0.90; P = 0.018). We also found that three SNPS in ZNF208 associated with CAD, respectively, rs2188971, rs8103163 and rs7248488. Linkage disequilibrium (LD) and haplotype analyses of the SNPs found that the CTA haplotype (rs1056675, rs1056654, rs11859599) and rs2188972A/rs2188971T/rs8103163A/rs7248488A (ATAA) were associated with CAD. Conclusion: In conclusion, the present study provided evidence that SNPs in the TNIP1, ZNF208 and MPHOSPH6 were associated with CAD in Chinese Han population. It is possible that these SNPs are CAD risk factors and these data can provide.