Active sp³ C–H Bond Oxidation Initiated sp³–sp² Consecutive C–H Functionalization of <i>N</i>-Arylglycine Amides: Construction of Isatins

Abstract

In the presence of catalytic triarylamine radical cation, an sp³-sp² consecutive C-H functionalization of N-arylglycine amides was achieved, providing a series of isatin derivatives in high yields. In this transformation, the initial aerobic oxidation of the relatively active sp³ C-H bonds triggered the following intramolecular cyclization, in which the aniline group was employed as a removable auxiliary group to enable the consecutive process.