Corticosteroid and long‐acting ß‐agonist therapy reduces epithelial goblet cell metaplasia

Abstract

Corticosteroid treatment inhibits IL-13-induced GCM of the airways in asthma, possibly through its effects on SPDEF and FOXa2 regulation of mucin gene expression. These effects are modestly augmented by the addition of a long-acting ß-agonist. As we found evidence for drug treatment counteracting the effects of IL-13 on the epithelium, we conclude that further exploration into the mechanisms by which corticosteroids and long-acting β₂ -adrenergic agonists confer protection against pathologic airway changes is warranted.