Nanocomposite of MoS₂-RGO as Facile, Heterogeneous, Recyclable, and Highly Efficient Green Catalyst for One-Pot Synthesis of Indole Alkaloids

Abstract

A nanocomposite comprised of MoS 2 -RGO having unique structural features was developed by using a facile preparation strategy and demonstrated to be a highly efficient heterogeneous catalyst for the synthesis of indole alkaloids in water. The catalyst could be recycled six times without significant loss of its activity. Green chemistry matrix calculations for the reaction showed high atom economy (A.E. = 94.7%) and small E -factor (0.089). Using this nanocomposite as catalyst, four naturally occurring indole alkaloids, Arundine, Vibrindole A, Turbomycin B, and Trisindole, were synthesized along with their other derivatives in excellent yields.