Studies of blood group antibodies. IV. Physicochemical differences between isoanti-A,B and isoanti-A or isoanti-B.

Abstract

Summary Both before and after receipt of a specific antigenic stimulus, individuals of blood group O tend to produce isoagglutinin (predominantly of sedimentation value S7) which migrates electrophoretically with the γ 2 -globulins, whereas subjects of blood groups A and B tend to produce isoagglutinin of predominantly S19 sedimentation value which migrates with the γ 1 -globulins. The implications of these findings in the reactive patterns of certain disease states are discussed.