Reagent‐Free C−H/N−H Cross‐Coupling: Regioselective Synthesis of N‐Heteroaromatics from Biaryl Aldehydes and NH₃

Abstract

An unprecedented synthesis of N-heteroaromatics from biaryl aldehydes and NH₃ through reagent-free C-H/N-H cross-coupling has been developed. The electrosynthesis uses NH₃ as an inexpensive and atom-economic nitrogen donor, requires no oxidizing agents, and allows efficient and regioselective access to a wide range of phenanthridines and structurally related polycyclic N-heteroaromatic products.