PubMed · 2016 · 43 citations · 0 references
MedicineOrthopaedic SurgeryOrthopedic SurgeryCell TherapyOrthopedicsRegenerative MedicineCartilage DegenerationCartilage RegenerationIntra-articular TherapyMesenchymal Stem Cell TherapyMesenchymal Stromal Cell TherapyOsteoarthritisIntra-articular AdministrationJoint Function AssessmentKnee Joint AssessmentMesenchymal Stem Cell EngraftmentMesenchymal Stem Cell SeedingUmbilical Cord-derived CellsUmbilical Cord-derived Mesenchymal Stem CellsUmbilical Cord-derived Mesenchymal Stromal Cells
OBJECTIVE: To investigate the safety and efficacy of human umbilical cord mesenchymal stem cells (MSCs) by intra-articular injection for degenerative knee osteoarthritis. METHODS: >0.05). The clinical efficacy was evaluated by SF-36 scale score, Lysholm score, and WOMAC score. RESULTS: <0.05). CONCLUSIONS: It can significantly improve the joint function and quality of life to use intra-articular injection of human umbilical cord MSCs for treating degenerative knee osteoarthritis. It takes effect after 1 month and the treatment effect can be sustained for 6 months.