The number of CD56dim NK cells in the graft has a major impact on risk of disease relapse following allo-HSCT

Abstract

population of mature effector cells and that high-level expression of the activatory protein DNAM on donor NK cells was also strongly protective. These observations offer important insights into the mechanism of GVL and suggest that optimization studies of the number of NK cells within the stem cell graft should be considered as a means to reduce disease relapse.