The bile acid‐sequestering resin sevelamer eliminates the acute <scp>GLP</scp> ‐1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes - Concepedia

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The bile acid‐sequestering resin sevelamer eliminates the acute <scp>GLP</scp> ‐1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes

42

Citations

33

References

2017

Year

Andreas Brønden, Anders Albèr, Ulrich Rohde, Lærke S. Gasbjerg, Jens F. Rehfeld, Jens J. Holst, Tina Vilsbøll, Filip K. Knop

Diabetes Obesity and Metabolism

Abstract

Single-dose administration of sevelamer eliminated bile acid-mediated GLP-1 secretion in patients with type 2 diabetes, which could be explained by reduced bile acid stimulation of the basolaterally localized TGR5 on enteroendocrine L cells.

References

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