Long-Term Natural Course of Small Nonfunctional Pancreatic Neuroendocrine Tumors in MEN1—Results From the Dutch MEN1 Study Group

Abstract

The majority of small NF-pNETs are stable at long-term follow-up, irrespective of the underlying MEN1 genotype. A subgroup of tumors is slowly growing but cannot be identified on clinical grounds. In this subgroup, tumors with missense mutations exhibited faster growth. Additional events appear necessary for pNETs to progress. Future studies should be aimed at identifying these molecular driving events, which could be used as potential biomarkers.