Pulmonary CCR2⁺CD4⁺T cells are immune regulatory and attenuate lung fibrosis development

Abstract

Pulmonary CCR2⁺CD4⁺ T cells are immunosuppressive, and could attenuate lung inflammation and fibrosis. Therapeutic strategies completely abrogating CCR2-dependent signalling will therefore also eliminate cell populations with protective roles in fibrotic lung disease. This emphasises the need for a detailed understanding of the functions of immune cell subsets in fibrotic lung disease.