Increased Autolysis of<i>μ</i>-Calpain in Skeletal Muscles of Chronic Alcohol-Fed Rats

Abstract

In summary, our data suggest that prolonged chronic alcohol consumption for 6 months resulted in increased autolysis of μ-calpain in rat skeletal muscles. These changes were accompanied by reduced titin and nebulin contents, titin hyperphosphorylation, and development of hindlimb muscle atrophy in the alcohol-fed rats.