Synthesis of Fluorinated Benzo[a]quinolizidines <i>via</i> Visible Light‐induced Tandem Substitution of Two Fluorine Atoms in a CF₃ Group

Abstract

Abstract An efficient method for the construction of fluorinated benzo[a]quinolizidines from α‐trifluoromethyl alkenes and dihydroisoquinoline acetic acids using visible light photocatalysis was developed. The reaction was accomplished through a decarboxylative/defluorinative cross‐coupling, followed by an intramolecular defluorinative C−H functionalization in one‐pot. Diversified fluorinated benzo[a]quinolizidines, which are less accessible by other methods, were obtained in good yields with high diastereoselectivity. magnified image