<i>In Vitro</i> Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae

Abstract

<i>Neisseria gonorrhoeae</i> is one of the leading antimicrobial resistance threats worldwide. This study determined the MICs of closthioamide to be 0.008 to 0.5 mg/liter for clinical <i>N. gonorrhoeae</i> strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant <i>N. gonorrhoeae</i>.