Emerging infectious diseases · 2017 · 54 citations · 4 references
MedicinePharmacologyPharmacotherapyAntimicrobial PharmacotherapyClinical PharmacologyPulmonologyDrug-susceptible Tuberculosis TreatmentPulmonary TuberculosisTuberculosis CareTuberculosis PharmacotherapyCombination Therapy For TuberculosisExtensively Drug-resistant Tuberculosis TreatmentMultidrug-resistant Tuberculosis TreatmentQt Interval AnalysisRespiratory InsufficiencyTuberculosis Treatment Regimens
We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.
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