Electrochemical Determination of Isoniazid at Electrochemically reduced graphene oxide modified Electrode

Abstract

The electrochemical determination of Isoniazid (INZ) was reported based on the electrochemically reduced graphene oxide (ERGO) modified glassy carbon electrode (GCE). ERGO was prepared by electrochemical reduction of graphene oxide (GO) in the pH 5.0 solution. As prepared ERGO was characterized by Scanning electron microscopy and electrochemical impedance spectroscopy. Linear sweep voltammetry was employed for the electrochemical determination of INZ. ERGO modified GCE has superior electrocatalytic activity towards INZ than GO and Bare GCE electrodes. Moreover, the linear range for INZ has been found from 2 μM to 70 μM with a LOD of 0.17 μM. Furthermore, the sensitivity of the proposed electrode towards INZ was found as 3.987 μA μM-1cm-2. Additionally, ERGO/GCE modified electrode has exhibits good reproducibility, repeatability with storage stability.