Proceedings of the National Academy of Sciences · 2017 · 117 citations · 49 references
Life SciencesMolecular BiologyPhysiologyCircadian RhythmsGene ExpressionTranscriptional RegulationCircadian EndocrinologyCircadian Gene ExpressionCircadian Molecular MechanismsCircadian PhysiologyCircadian Regulation Of MetabolismNuclear ReceptorsCircadian ClocksCircadian MetabolismCircadian Transcriptional ControlCircadian Transcriptional RegulationLigand Recognition MotifsReceptor Recognition MotifsTranscriptional Feedback ControlTranscriptional Repressors
Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like 1 (BMAL1), and transcriptional repressors cryptochrome (CRY) and period (PER). CRY1 and CRY2 bind independently of other core clock factors to many genomic sites, which are enriched for NR recognition motifs. Here we report that CRY1/2 serve as corepressors for many NRs, indicating a new facet of circadian control of NR-mediated regulation of metabolism and physiology, and specifically contribute to diurnal modulation of drug metabolism.
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Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Satchidananda Panda, Marina P. Antoch, Brooke H. Miller et al. · Cell · 2002 · 2.3K citations · Full text
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
David M. Heery, Eric Kalkhoven, Susan Hoare et al. · Nature · 1997 · 2.1K citations