Science Translational Medicine · 2017 · 336 citations · 40 references
Life SciencesNeurobiologyNeuroscienceBehavioral NeuroscienceMolecular NeurobiologyMolecular NeuroscienceDevelopmental Social NeuroscienceExcitatory-inhibitory BalanceNeurodevelopmental DisordersNeuromodulationNeurotransmissionSynaptic TransmissionCortical Excitation-inhibition BalanceCortical Excitatory-inhibitory BalanceExcitatory Pyramidal NeuronsFiber PhotometryOptogenetic StimulationPrefrontal Cortex FunctionSocial Behavior AlterationsTemporal Control Of Neural Activity
knockout mice. Together, these results suggest that real-time modulation of E:I balance in the mouse prefrontal cortex can rescue social behavior deficits reminiscent of autism phenotypes.
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