Reactive oxygen species-based measurement of the dependence of the Coulomb nanoradiator effect on proton energy and atomic <i>Z</i> value

Abstract

The ROS-based detection of the CNR effect revealed its dependence on the proton beam energy, dose and atomic Z value and provided insight into the low-linear energy transfer (LET) CNR radiation, suggesting that these factors may influence the therapeutic efficacy via chemical reactivities, transport behaviors, and intracellular oxidative stress.