Cardioprotective effects of 5‐hydroxymethylfurfural mediated by inhibition of L‐type Ca²⁺ currents

Abstract

Our data revealed a cardioprotective effect of 5-HMF in I/R that is mediated by inhibition of L-type Ca²⁺ channels. Thus, 5-HMF is suggested as a beneficial additive to cardioplegic solutions, but adverse effects and contraindications of Ca²⁺ channel blockers have to be considered in therapeutic application of the drug.