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Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats

First-pass EffectMolecular PharmacologyPharmacological StudyBiochemistryMedicineIsorhynchophylline EpimersPhysiologyStereoselective PharmacokineticsMetabolismPharmacologyPharmacokinetics