Angewandte Chemie International Edition · 2017 · 88 citations · 42 references
Natural SciencesChemistryInorganic ChemistryOrganic ChemistryHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisAmination ReactionsAromatic Nucleophilic SubstitutionNitrogen HeterocyclesNucleophilic Substitution In HeterocyclesStereoselective Amination
A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.
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Dirhodium-catalyzed C-H arene amination using hydroxylamines
Mahesh P. Paudyal, Adeniyi Michael Adebesin, Scott R. Burt et al. · Science · 2016 · 286 citations · Full text