Frequent <i>GNAQ, GNA11</i> , and <i>EIF1AX</i> Mutations in Iris Melanoma

Abstract

In this most comprehensive genetic analysis of iris melanomas published to date, we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ, GNA11, and EIF1AX mutations. Future studies will need to assess if screening mutation profiles in iris melanomas may be of diagnostic or prognostic value.