Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

Bo Hu, Eran Elinav, Samuel Huber et al. · Proceedings of the National Academy of Sciences · 2010 · 440 citations

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

Mohamed Lamkanfi, Thirumala‐Devi Kanneganti, Petra Van Damme et al. · Molecular & Cellular Proteomics · 2008 · 338 citations · Full text

Immunology, Salmonella Infection, Inflammation +18

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

Peter Schäfer, Anastasia Parton, Lori Capone et al. · Cellular Signalling · 2014 · 302 citations · Full text

Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases

Georg Schett, Victor S. Sloan, Randall M. Stevens et al. · Therapeutic Advances in Musculoskeletal Disease · 2010 · 163 citations · Full text

Phosphodiesterase 4, Immunology, Cell Death +21

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

Fiona E. McCann, Andrew C. Palfreeman, Melanie R. Andrews et al. · Arthritis Research & Therapy · 2010 · 131 citations · Full text