Copper‐Catalyzed Aminodifluoroalkylation of Alkenes with α‐Bromodifluoroacetamides: Synthesis of 3,3‐Difluoropyrrolidin‐2‐ones

Abstract

Abstract Copper‐catalyzed external‐oxidant‐free regioselective aminodifluoroalkylation of alkenes with readily available α‐bromodifluoroacetamides was realized. This reaction exhibits good functional group tolerance with respect to alkenes and α‐bromodifluoroacetamides in affording 3,3‐difluoropyrrolidin‐2‐ones. A mechanism involving copper‐catalyzed generation of a difluoroalkyl radical is proposed. magnified image