Signal‐Regulated Protein Kinases/Protein Kinase B‐p53‐BH3–Interacting Domain Death Agonist Pathway Regulates Gingipain‐Induced Apoptosis in Osteoblasts

Abstract

The present findings suggest that Bid plays an essential role in gingipain-induced osteoblast apoptosis, which is dependent on inhibition of ERK and PKB phosphorylation, followed by the activation of p53.