<i>TNF-α</i> Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus

Abstract

The GA genotype of the TNF-α -308G>A polymorphism is a significant genetic risk factor for the pathogenesis of KC. Moreover, this single nucleotide polymorphism (SNP) was observed to be associated with deregulated expression of downstream molecules, thus further reinforcing the role of the inflammatory pathway components in the development of KC.