Organic Letters · 2017 · 53 citations · 64 references
Natural SciencesChemical EngineeringChemistryCatalysisOrganic ChemistryReaction EngineeringCatalyst PreparationCatalytic MaterialsCatalytic MechanismsCross-coupling ReactionsHeterocycle SynthesisMetal CatalysisBenzylic FunctionalizationC - H Bond FunctionalizationHeterocycle FunctionalizationIron CatalysisIron-catalyzed Cross-couplingScopeTriazole ChemistryTriazole Synthesis
The design of trisubstituted triazoles set the stage for proximity-induced iron-catalyzed C-H activation of benzyl and aryl amines with ample scope. Thereby, C-H alkylations and C-H arylations proved viable with high levels of chemo and positional selectivities by means of racemization-free iron catalysis with the reusable triazole being removed in a traceless fashion.
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