Concepedia

Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4(3H)-one derivatives as potential PPARγ and SUR agonists

Mohamed K. Ibrahim, Ibrahim H. Eissa, Mohamed S. Alesawy, Ahmed M. Metwaly, Mohamed M. Radwan, Mahmoud A. ElSohly

Bioorganic & Medicinal Chemistry · 2017 · 86 citations · 41 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsLead Compound DesignLigand BindingLigand-based DesignQuantitative Structure-activity RelationshipsReceptor ModelingStructure-activity Relationship Analysis3D Molecular ModelingChemical Synthesis Of AnaloguesMedicinal Chemistry ApplicationsMolecular Property-based DesignReaction-based Molecular DesignStructure-activity Relationships Of Activators

References

41

Applied Regression Analysis

Technometrics · 2005 · 18.1K citations

Business, Biostatistics, Mathematics +17

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

John Dormandy, B Charbonnel, D.J.A. Eckland et al. · The Lancet · 2005 · 4.1K citations · Full text

Medicine, Internal Medicine, Pharmacotherapy +15

Alexander Golbraikh, Alexander Tropsha · Journal of Molecular Graphics and Modelling · 2002 · 3.7K citations

Microvascular and Macrovascular Complications of Diabetes

Michael J. Fowler · Clinical Diabetes · 2008 · 1.9K citations

Medicine, Internal Medicine, Pharmacotherapy +17

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

Steven A. Kliewer, Barry M. Forman, Bruce Blumberg et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

Life Sciences, Developmental Biology, Molecular Biology +15