Silver‐Catalyzed Oxidative C(sp³)−P Bond Formation through C−C and P−H Bond Cleavage

Abstract

The silver-catalyzed oxidative C(sp³ )-H/P-H cross-coupling of 1,3-dicarbonyl compounds with H-phosphonates, followed by a chemo- and regioselective C(sp³ )-C(CO) bond-cleavage step, provided heavily functionalized β-ketophosphonates. This novel method based on a readily available reaction system exhibits wide scope, high functional-group tolerance, and exclusive selectivity.