Big conductance calcium‐activated potassium channel openers control spasticity without sedation

Abstract

We identified the neuronal form of the BK_Ca channel as the target for VSN16R and demonstrated that its activation alleviates neuronal excitability and spasticity in an experimental model of MS, revealing a novel mechanism to control spasticity. VSN16R is a potential, safe and selective ligand for controlling neural hyper-excitability in spasticity.