Journal of Biomedical Optics · 2008 · 38 citations · 2 references
AgricultureCrop SciencesPlant SciencesGermplasm EvaluationPlant Genetic ResourcesPlant GeneticsAgronomic Performance EvaluationAgronomic Trait EvaluationGenetic Diversity AssessmentGermplasm CharacterizationGermplasm CollectionGermplasm ResourcesAllelic Frequency VariationAllelic Variation AnalysisAllelic Variation DetectionPhenotypic Diversity AssessmentSeed Coat Color GeneticsSeed Germplasm EvaluationSeed Shape VariationVegetative Development Stages
Optical coherence tomography angiography (OCTA) is clinically useful for the qualitative assessment of the macular microvasculature. However, there is a need for comprehensive quantitative tools to help objectively analyze the OCT angiograms. Few studies have reported the use of a single quantitative index to describe vessel density in OCT angiograms. In this study, we introduce a five-index quantitative analysis of OCT angiograms in an attempt to detect and assess vascular abnormalities from multiple perspectives. The indices include vessel area density, vessel skeleton density, vessel diameter index, vessel perimeter index, and vessel complexity index. We show the usefulness of the proposed indices with five illustrative cases. Repeatability is tested on both a healthy case and a stable diseased case, giving interclass coefficients smaller than 0.031. The results demonstrate that our proposed quantitative analysis may be useful as a complement to conventional OCTA for the diagnosis of disease and monitoring of treatment.
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