Effect of myelin water exchange on DTI‐derived parameters in diffusion MRI: Elucidation of TE dependence

Abstract

The exchange between myelin and intra/extra-axonal water pools often plays a non-negligible role in the observed TE dependence of diffusion parameters, which may accompany or alter the effect of intrinsic T₂ in causing such dependence. The TE dependence may potentially serve as a biomarker for demyelination processes (e.g., in multiple sclerosis and Alzheimer's disease). Magn Reson Med 79:1650-1660, 2018. © 2017 International Society for Magnetic Resonance in Medicine.