Concepedia

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

Janet Woodcock, Lisa M. LaVange

New England Journal of Medicine · 2017 · 1K citations · 19 references

DOIFull text

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Concepts

Abstract

This review considers master protocols, which involve the study of one or more interventions in multiple diseases or of a single disease with multiple interventions.

References

19

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

Jeffrey A. Lieberman, T. Scott Stroup, Joseph P. McEvoy et al. · New England Journal of Medicine · 2005 · 5.9K citations · Full text

, , +14

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

Randall J. Bateman, Chengjie Xiong, Tammie L.S. Benzinger et al. · New England Journal of Medicine · 2012 · 3.8K citations · Full text

, , +16

Vemurafenib in Multiple Nonmelanoma Cancers with <i>BRAF</i> V600 Mutations

David M. Hyman, Igor Puzanov, Vivek Subbiah et al. · New England Journal of Medicine · 2015 · 1.7K citations · Full text

, , +12

The BATTLE Trial: Personalizing Therapy for Lung Cancer

Edward S. Kim, Roy S. Herbst, Ignacio I. Wistuba et al. · Cancer Discovery · 2011 · 893 citations

, , +17

I-SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy

AD Barker, C C Sigman, Kelloff Gj et al. · Clinical Pharmacology & Therapeutics · 2009 · 766 citations

, , +17