Synthesis of 2‐Amino‐1,3,4‐oxadiazoles through Elemental Sulfur Promoted Cyclization of Hydrazides with Isocyanides

Abstract

A novel sulfur‐promoted cyclization of hydrazides and isonitriles to produce 1,3,4‐oxadiazole has been developed. The method is operationally simple and compatible with a wide scope of substrates and various 2‐amino‐ 1,3,4‐oxadiazoles are efficiently obtained in good yields.