Expanded phenotypes and outcomes among 256 <scp>LGI</scp> 1/ <scp>CASPR</scp> 2‐ <scp>I</scp> g <scp>G</scp> –positive patients

Abstract

Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1-IgG. Response to initial immunotherapy is often favorable, but some patients remain severely disabled, requiring long-term immunotherapy and/or antiepileptic medications. Ann Neurol 2017;82:79-92.