Copper-Catalyzed Direct Nitration on Aryl C–H Bonds by Concomitant Azidation–Oxidation with TMS Azide and TBHP under Aerobic Conditions

Abstract

An unprecedented copper-catalyzed in situ azidation-oxidation for the nitration of anilides and sulfonamides has been developed by direct C_Ar-H functionalization. This novel and efficient nitration protocol is achieved employing TMSN₃ and TBHP without the exclusion of air or moisture. The synthetic applications of the 2-nitroanilides have been explored.