Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs - Concepedia

Concepedia

Publication | Closed Access

Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs

14

Citations

45

References

2017

Year

Jana Křížová, Hana Štufková, Marie Rodinová, Monika Mačáková, Božena Bohuslavová, Daniela Vidinská, Zdeňka Ellederová, A. Pavlok, David Howland, J Zeman,

Neurodegenerative Diseases

Abstract

Our results suggest a link between the gain of toxic function of mutated huntingtin in TgHD spermatozoa and the observed MM and/or glycolytic impairment. We determined 4 biomarkers useful for HD phenotyping and experimental therapy monitoring studies in TgHD minipigs.

References

	Year	Citations

Page 1