Effect of Genetic Variation in<i>UGT1A</i>and<i>ABCB1</i>on Moxifloxacin Pharmacokinetics in South African Patients with Tuberculosis

Abstract

Genetic variation in UGT1A as represented by rs8175347 to a lesser extent rs3755319 and the ABCB1 rs2032582 SNP is modestly associated with the interindividual variability reported in moxifloxacin pharmacokinetics and exposure. Clinical relevance of the effects of genetic variation on moxifloxacin pharmacokinetic requires further investigation.