Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp²–H/Csp³–Csp³ Activation

Abstract

A Rh(III)-catalyzed carboamination of alkynyl cycloalkanols with arylamines has been developed. This transformation involves a novel Csp²-H/Csp³-Csp³ activation relay and provides an efficient approach to versatile 1,2,3-trisubstituted indoles with a broad range of functional group tolerance.