Methods for synthesis of N-heterocyclyl/heteroaryl- α-aminophosphonates and α-(azaheterocyclyl)phosphonates

Abstract

This review describes the most frequently reported synthetic methods for N-heterocyclyl-aminophosphonic acids and their mono-or di-esters bearing a heterocyclic or heteroaryl system at the nitrogen atom, as well as methods for the synthesis of -(azaheterocyclyl)phosphonates. The Pudovik and Kabachnik-Fields reactions are the main pathways for construction of these features besides other miscellaneous methods.