Concepedia

A reverse genetics system for avian coronavirus infectious bronchitis virus based on targeted RNA recombination

Steven J. van Beurden, Alinda J. Berends, Annika Krämer-Kühl, Dieuwertje Spekreijse, Gilles Chénard, Hans-Christian Philipp, Egbert Mundt, Peter J. M. Rottier, Monique H. Verheije

Virology Journal · 2017 · 46 citations · 32 references

DOIFull text

Open access

Abstract

Targeted RNA recombination allows for the generation of recombinant IBV strains that are not able to infect and propagate in continuous cell lines. The ability to introduce specific mutations holds promise for the development of rationally designed live-attenuated IBV vaccines and for studies into the biology of IBV in general.

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