Is the Intrinsic Genomic Activity of Thyroxine Relevant <i>In Vivo</i> ? Effects on Gene Expression in Primary Cerebrocortical and Neuroblastoma Cells

Abstract

T4 has intrinsic genomic activity. Positive regulation depends on the cell context, and primary cells appear much more sensitive than neuroblastoma cells. In all cells, negative regulation is more sensitive to T4 than positive regulation. These properties may explain the mostly normal gene expression in the brain of Dio2-deficient mice.