The AMP-Related Kinase (AMPK) Induces Ca ²⁺ -Independent Dilation of Resistance Arteries by Interfering With Actin Filament Formation

Abstract

AMPK induces actin depolymerization, which reduces vascular tone and the response to vasoconstrictors. Our findings demonstrate a new role of AMPK in the control of actin cytoskeletal dynamics, potentially allowing for long-term dilation of microvessels without substantial changes in cytosolic Ca²⁺.