Organic Letters · 2017 · 39 citations · 72 references
Natural SciencesChemistryCatalysisOrganic ChemistryAddition ReactionsCross-coupling ReactionsDiversity-oriented SynthesisHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisAlkyne Cycloaddition ReactionsAsymmetric Heterocycle SynthesisBenzofuran ChemistryHeterocycle FunctionalizationUmpolung Strategy
A phosphine-catalyzed domino process of benzofuranones with allenoates has been developed which furnishes highly functionalized unsymmetrical 3,3-disubstituted benzofuranones in synthetically useful yields. The mechanism for the transformation is a tandem β-umpolung/γ-umpolung process.
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