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Drug Resistance Mechanism of L10F, L10F/N88S and L90M mutations in CRF01_AE HIV-1 protease: Molecular dynamics simulations and binding free energy calculations

Crf01_ae Hiv-1 ProteaseProtein AssemblyProtein FoldingNatural SciencesHuman RetrovirusDrug Resistance MechanismAntiviral Drug DevelopmentMolecular BiologyResistance Mutation (Virology)Free Energy CalculationsHivMedicineMolecular DynamicsBiomolecular Engineering