Spontaneous food allergy in <i>Was</i>^{<i>−/−</i>} mice occurs independent of Fcε<scp>RI</scp>‐mediated mast cell activation

Abstract

Was^-/- mice provide a model of food allergy with the advantage of mimicking polysensitization and low food-antigen IgE titers as observed in humans with clinical food allergy. This model will facilitate studies on aberrant immune responses during spontaneous disease development. Our results imply that therapeutic targeting of the IgE/FcεRI activation cascade will not affect sensitization to food.