Interferon-γ mediates the immunosuppression of bone marrow mesenchymal stem cells on T-lymphocytes <i>in vitro</i>

Abstract

Human MSCs constitutively expressed immunosuppressive levels of PGE₂, HGF and TGF-β₁. The proinflammatory cytokine IFN-γ exhibited synergistic effects with MSCs on immunosuppression, possibly by up-regulating PGE₂, HGF and TGF-β₁ in MSCs and inducting MSCs expression of IDO, involved in tryptophan catabolism.