Concepedia

The transcriptional repressor GATAD2B mediates progesterone receptor suppression of myometrial contractile gene expression

Chien-Cheng Chen, Alina P. Montalbano, Imran Hussain, Wan-Ru Lee, Carole R. Mendelson

Journal of Biological Chemistry · 2017 · 11 citations · 50 references

DOIFull text

Open access

Concepts

Abstract

-PR suppression of proinflammatory and contractile genes during pregnancy. Decreased GATAD2B expression near term may contribute to the decline in PR function, leading to labor.

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