Episodic replacement of clotting factor concentrates does not prevent bleeding or musculoskeletal damage – the <scp>MUSFIH</scp> study

Abstract

Episodic CFC replacement over a large range of doses does not alter the natural course of bleeding in haemophilia or the musculoskeletal deterioration and should not be recommended as a long term option for treatment. Prophylaxis is the only way to preserve musculoskeletal function in haemophilia.